Bap31 Is an Itinerant Protein that Moves between the Peripheral ER and a Juxtanuclear Compartment Related to ER-associated Degradation

نویسندگان

  • Yuichi Wakana
  • Sawako Takai
  • Ken-ichi Nakajima
  • Katsuko Tani
  • Akitsugu Yamamoto
  • Peter Watson
  • David J. Stephens
  • Hans-Peter Hauri
  • Mitsuo Tagaya
چکیده

School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan; Department of Cell Biology, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom, and Department of Pharmacology and Neurobiology, University of Basel, Basel CH-4056, Switzerland

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Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation.

Certain endoplasmic reticulum (ER)-associated degradation (ERAD) substrates with transmembrane domains are segregated from other ER proteins and sorted into a juxtanuclear subcompartment, known as the ER quality control compartment. Bap31 is an ER protein with three transmembrane domains, and it is assumed to be a cargo receptor for ER export of some transmembrane proteins, especially those pro...

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Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum.

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تاریخ انتشار 2008